A few major recommendations combining superb wines and unique wineries some of which require reservations:
1) Caymus - attractive small sit down tasting room
2) Round Pond - Beautiful new facility tasting includes wine and food pairing
3) Hall - Make an appointment at their Rutherford facility
4) Far Niente- If someone in your party is a member of the trade
5) Patz and Hall - especially if you like Pinot's and Chardonnays
I may have some additional recommendations if you like particular varietals