Of course!
I'd first recommend walking around Mitte to get the historical insight. If you're in a hurry, buses 100 and 200 and the S-Bahn between Alexanderplatz and Zoologischer Garten can do the job.
- Brandenburg Gate
- Reichstag
- Unter den Linden
- Potsdamer Platz
- Checkpoint Charlie
- The wall @ Niederkicherstrasse, East Side Gallery or Bernauer Strasse
- Gendarmenmarkt
- Museuminsel
- Oranienburger Strasse
- Kurfürstendamm
This is the basics, though it can be adjusted to your own preferences. Having worked as a tour guide in Berlin, you're welcome to reply or PM me for any questions.