depends on your physical tolerence to those things, I guess.

For me, 10mg of zolpidem/Ambien plus a few cocktails and glasses of champagne would do me justice for a 6hr nap. But I think there might have been cases of people dying in flight and the sedatives were to blame. Oh also, if you have a business meeting right after you land, it is probably better to show up at work groggy and tired, rather than drugged-up and hangover/drunk like -> I think.