Assuming you're working on Delta MR's since you're in MSP, the deals all seem to leverage the BNA/RDU/STL/PIT double MQM deal.

I now live in New Orleans but commute to MSP often. New Orleans is difficult for mileage runs so positioning seems a given. I tried looking at domestic MR's from those cities, especially combined with travel I was already trying to do such as a conference in LAS, but never could make it really work.

The MR forum lists a few DL MR's. The Singapore is the furthest and seems likely to have the lowest CPM after positioning but is obviously a big commitment. LIM seems like a good one. All of them probably require a weekday or two to make work.