I'd take the single seat in the middle.
I was on a window seat with no one next (or in front) to me last time I flew from EWR to GVA. I was sleeping after the meal and when I woke up the aisle seat in front of me was being used as crew rest and I could barely get out without bumping into, thus waking up, the guy.

Like this:
I'm the second bold X.

XX X XX
XX X XX
XX X XX
XX X XX
XX X XX