Originally Posted by
BobH
Hampton Inn -- it's less than a block from a light rail stop and walking distance from the Amtrak station.
They'll also pick you up at the airport.
Bob H
Just to clarify that's the Hampton Inn San Diego-Downtown, not the HI that's up north by the airport. I've stayed here a couple of times and it's a nice hotel. The Embassy Suites San Diego Bay - Downtown is also in the same area and would work for you too.