As a few others have said succinctly, there are numerous downsides to seriously heavy business travel. Your life ceases to be your own, and instead is dictated by where you're off to next, with other essential life stuff having to be crammed into the small amount of time you have at home. It's tough on relationships, and you invariably miss important things like weddings and christenings, as well as losing touch with numerous friends because you're never there. There have been quite a few occasions when I've been about to head off to somewhere I really didn't want to go to (despite nice lounges and a great hotel the other end), because my friends were all doing something far more fun like going down the pub for the bank holiday!

That said, I still wouldn't change - but I'm quite lucky. Although I pull some fairly ridiculously hectic schedules, I don't have to work too hard when I'm actually away (unlike most) and I have a reasonable degree of choice about whether I want to go somewhere or not.