I live in Indy and have a lot of family in Evansville so I make it down there a few times a year. Trust me, the drive to EVV from Louisville and Nashville is much better than the drive from Indy. Even St. Louis is better than the drive from Indy. You can get to Evansville from Louisville in under 2 hours.

If you are wanting to fly Delta and can get a direct flight to CVG then you might want to drive from there. It's probably about a 3 hour drive.