It's really just an effect of where the Vdara building sits, on the CityCenter site. Depending on where on the Strip one is heading, it may be faster to access the Strip via the Bellagio spa tower (via the enclosed bridge). South strip might be accessed via the Monte Carlo (tram), and so on.

Some people are more directionally-confused than others, so it may be a YMMV situation. But Vdara does have some distinct advantages (suites with kitchens, nonsmoking, non-gaming but with casino two minutes away) that would make it desirable to many.