As a native San Franciscan who likes dining, I have been to most of these places mentioned above including French L, Masa's, Gary D's, Fleur de Lys, La Folie, Ritz Carlton Dining Room, Aqua, Michael Mina, Campton Place, Coi, and Cyrus. I have not been to Manresa.

For a really unique experience, you cannot go wrong with French Laundry. I think you cannot go wrong with the Ritz dining room, either. It is just classic luxury. Cyrus is far out there geographically, but I think it is worthy of its two Michelin stars. It is a great place. Gary D's is in the same league as the others food-wise, but ambiance wise it is somewhat crowded. Masa's is very romantic, Michael Mina is less so. Fleur de Lys tends to be more on the older side clientelle wise. Aqua is over-rated and does not have very good food. Campton place has lost their chef, and Coi's food is very strange. If it were me, I would pick French Laundry, Cyrus, Ritz Carlton, Gary D's, or Fleur de Lys.