Hi Skywalker22,
I would guess that the answer is "yes" there is a best program for you. Based specifically on your priorities and situation. Figuring out what it is, is another question!
I would guess that the experts here in the FlyerTalk Forums would be likely to proffer some advice if you shared a bit more about your situation. Are you hoping for award flights? Are you more interested in upgrades? How much do you fly?
Though I am not an expert myself, I did find a summary discription of some of the top programs that is going to be in the April issue of Conde Nast Traveler that was written by one of FT's experts gleff. I hope you find it useful (see link below.)
http://www.concierge.com/cntraveler/articles/502453