You might want to check out these folks:
http://www.theveniceexperience.com/
This is run by a couple from Baltimore who moved to Venice. You will have to pay for them to guide you around, but if you get more people you can split the costs.
Or, if you want to go it alone, check out Rick Steves web site for suggestions:
http://www.ricksteves.com/plan/desti...y/nlpubven.htm
We didn't spend enough time in Venice to do this, but maybe next time. Enjoy and report back on your experience.