I had a couple like this on my PHX-BUR flight last month. It was a young woman who was either drunk or just very loopy and an older man next to her. At one point while on the ground at PHX I sighed and she said "oh, am I annoying you?" to me?

During the flight I used my noise canceling headsets (best $300 I ever spent) but upon approach she was yapping again to the point where she poked me in the shoulder to offer me a business card. I dropped it in the seatback.

I don't mind people who talk, I just wish they'd leave me alone. Usually I wear my headsets and if I don't have them with me for whatever reason I can always ask them to keep it down.