Yes, In-n-out burgers really are that good. It was a life-changing experience the first time I had them in college.
As for the fries, get them well done and animal style and then they are awesome too (if a bit artery clogging).
White castle and Five Guys are no comparison. I don't know why everybody likes Five Guys so much, the mushrooms they use on their burgers are straight out of a can! And the burgers are served in foil.
I can't wait to move back to California. In-n-out being one of the more major reasons of course.