I enjoy shooting in low light settings without flash, primarily small jazz venues, etc. With the high ISO required, noise can a significant problem. Noise reduction in LR2 sometimes helps a bit but I am not very impressed with it. Noise Ninja Standalone with the Sidekick mode seems a good choice.

Any other suggestions? Should I consider Neat Image?

(I use LR2 on a Mac, shoot entirely raw on a D700, and typically convert to dng when downloading images.)