Thanks for the input. We're 28 so we're up to it...plus I have a knack for cramming a lot of stuff into a short amount of time when traveling. We usually do need a vacation from the vacation but we get to experience a lot too.
What I probably need to do is research train times. I was thinking a 5-6 hour train ride to the Alps and a 5-6 hour train ride from there to Venice. So I figured 2 long train rides + 1 short flight wouldn't be bad. However, maybe we'd be better off leaving Paris at night and doing the overnight train since it sounds like that will be a long ride...or possibly fly if we can't do overnight as I'd hate to waste 4-5 days of time just traveling.