Ok, it's my turn to beg for a drink at the fountain of knowledge
I use Microsoft Document Imaging pretty much for all of my electronic printing - web pages, letters, etc. MDI is an nifty little (optional) component of MS Office, which creates a virtual printer and allows you to create pdf-like documents in .mdi format. I've always found it a lighter, cleaner and simpler alternative to Adobe, to say nothing of the fact that it's free (well, it's
included 
with MS Office at no extra charge)
Imperceptibly I started to experience problems opening .mdi files that I've created, with the following symptoms:
If I try to open a file, the little viewer app opens up and slows down the computer, almost to a halt. If nothing else is running I may succeed, after a minute or so after hitting Ctr-Alt-Del, in bringing up the Task Manager.
The task manager typically shows normal-to-low CPU and RAM utilization, however the hard drive continues to spin like crazy, even with a small (less than 1 MB) file, and it seems that that's what bogging down the system.
The same behavior is observed when trying to open a file I created on a different, ostensibly "clean", computer.
What I've done is uninstall and reinstall the MDI component in MS Office installer.
My initial thought was that perhaps my almost 90% full HD was to blame, as the files I create somehow become very fragmented, however like I said, when I try to open a file saved to a USB key on a clean computer, the same outcome is observed.
PLEASE HELP!
PS Running vista home, ms office 03