a thought about hotels. I have stayed in just about every hotel in that town except the 21C Museum Hotel. As far as downtown is concerned, if you ike old and charming the Seelbach (now a Hilton) is something to see at least once, especially its bar.
Otherwise, any of the chains is about as good as any of the others and par for their brands so it makes little difference which you try. I would avoid the Galt House for housekeeping reasons.