Once you pick a hotel to stay at, ask them to keep a bag of yours there so you can fly with just carry-on. Buy duplicates of all the liquids you need, plus some extra clothes, and little luxuries (perhaps a travel vase for flowers in your hotel room, a couple of pictures of family.)

My dh commuted from YOW - LAX (trans border, not just trans-states) for almost 3 years. He stayed at the same hotel (Residence Inn which we called "the cottage" since the kids and I would stay there for 4 weeks each summer plus spring break and they'd give us the same unit each stay, right over the tennis courts so the kids go outside and play without me supervising them.) Then for 2 years he alternated between YOW-LGA and YOW-IAD. In both cases he found an apartment hotel and would often receive the same room week after week.

In all cases he had a box of things kept by the hotel, including his favourite soups, soya sauce and other cooking supplies, so he didn't have to buy new each time or carry things back and forth.

Finally, make friends in your new city. One of my favourite lines from the "signs you travel too much" thread was from a person who belonged to two softball teams, neither of them were in his hometown!