Ryanair has service to many Eastern European cities, for example, Kaunas, Lithuania, that formerly had no service at all. People there used to take 24 hour bus rides to get to Germany. As long as total prices are kept in check those residents will take anything Ryanair throws at them. I book many such tickets for my Lithuanian relatives and the prices are usually around 50-100 euros total (if booked far enough in advance), including all tacked on fees.