In my experience, yes, In N Out is by far the best fast food burger chain I have ever experienced.
I think it's key to acknowledge what a few PPs have tried to point out: In N Out is a chain and was meant to outdo burger chains like McDonald's, not local mom and pop or your own backyard grill. In N Out is a CA chain. Most of us don't carry around a grill in our trunk to tail gate at the drop of a hat. If we want a burger while out, we're often stuck with whatever chain we find. In N Out is glorious in that you can get a great burger in so many places. The benefits of a chain, but the taste of a mom & pop store. Yes, some locations are unfortunately not as good as most, but luckily, those are quite the exception to the rule.
I'm not quite as enthusiastic about their fries and shake like most fans are. I just like the burgers.