I don't have any in particular. However, since it is a big banking area, it is a pretty wealthy city, and the nickname the locals give it is "Main-Hattan" as it has a modern skyline and it reminds then of New York City on the river Main!

Therefore, there should be plenty of night life for whatever floats your boat.

I really don't know much about museums there, other than the Jewish museum, which is housed in the old Rothhschild mansion. It was a good museum if you are interested in the history of the Jews in Germany, but it was infuriatingly mostly in German, although I bet most of their visitors are English speaking.

I hear that the Frankfurt Hilton is really nice, as it is one of the newer Hilton properties. You should enjoy it, and if you have the time, file a brief trip report!