The Park Hyatt (the ancient Park Plaza) is by the ROM and the fancy stores. The Intercontinental is nicer in the same location. The Hyatt Regency, which is the old Holiday Inn, is near sports and entertainment. The King Edward is near a hospital and some top restaurants and the Distillery District and some think it's elegant while the Sheraton Centre is in the middle of everything in terms of business and City Hall. The Westin Harbour Castle is interesting for the lake views and great rooms and Harbourfront. We always use Priceline and can get any of these for $45-55 per night. The Marriotts are both well-located as well. The Delta Chelsea is a Starwood and is the most popular and central. And Sutton Place is very fine and where the movie stars stay. The airport shuttle goes first to the Westin and ends up at the Chelsea. And there is the Hilton too! For weird, try The Gladstone.