for all you nay sayers,I do the opposite I usually drive from the EWR area to PHL. But lately its been cheaper fares out of EWR
OP if you are heading West PHL-CLE-XXX or PHL-IAH-XXX is no problem what so ever, except no non-stops. Its a hassle and usully expensive with a long layover if you are staying East of the Mississippi
theres always WN
but for most EC travel its either US

or up to EWR