Given that it was confirmed on here that ATO (After Take Off) occurs when the planes wheels have left the ground, I have been known to give it about two minutes before reclining and getting ready to sleep. Extremely helpful on a short overnight from BOS, and allows the maximum sleep time when one has to go straight to work after landing.
I asked a VS staffer at the Business Travel Show one year when one can turn the suite to a bed and he replied that it was possible after the fasten seatbelt light had been swithced off. He then explained that you had to get up to flip the seat over and to do that (without the cabin crew getting annoyed) the light had to be off. However you can be reclined in a VS Suite in seat mode, for take off.