I have not traveled with a senior Cat but will try to offer some suggestions.

First thign I would do is talk to your vet to see how your special Cat (I don't call the Cats with two digit ages senior) will do on a plane. I'm leary about giving a sediative too but maybe the vet can offer some suggestions.

Next: maybe mention to US Airways (if you haven't already done so) that you are traveling with a special Kitty and make sure there is space available for her to travel in a carrier in the main cabin (I would NOT check her as cargo.) Guessing you already done this but make sure there's space available for her to travel in the cabin. (check out rssrsvp's thread on Carry on Rules on this forum.)

When you are ready to take the other babies to their new home and you decide to drive read Kipper's thread on his travels with his dog. The rules like finding the right hotel and other travel tips can apply to Cats too.

Please keep us posted on this and Positive Cat vibes that your Feline children have a great journey to their new home.