I can highly recommend the HIX Messe. Location is 3 min away from the highway, being at the airport in max. 20 min. and not to far from the city center (15 min by bus, 5 min by car). All times calculated with clear streets
Hotel is quite new, clean and modern, with a good spread at breakfast (talking about a HIX)
If you have no problems with a no frill HIX, go with this one.
All other HI properties in Frankfurt are a little aged and donīt offer you essentialy more comfort than the HIX.
The HIX airport is a good choice if you have an early flight (8 EUR für Airport Shuttle), but itīs far away from Frankfurt.