Really depends what scale of company you work in. For example, a person I know of is an IT Director for a large, multi-national company, and travels long haul UK->DFW, LAX, SYD, HKG, SIN in a month. Sometimes takes in some of the above twice a month.

Obviously you can't go in at this level, but you can certainly work your way up to it - just depends if you have it in you.