Traveling to Rome from Prague in April
I am travelling to Berlin from NYC in April and diong a tour which ends in Prague after 10days then I am taking a tour in Italy for 10 days. I need to travel from Prague to Italy on 17th April and be at Rome on 18th April by 5pm. Which is the easiest way, if I travel by train/flight? If I take a flight I might need a hotel for 1 night in Rome or Prague. Since I am single female traveller, i need to take into account safety. Ahs anyone got any suggestions?