LH F to Argentina? I would not wait a second to book this. One of the longest flights on the network, so it is really worth it.
Upper deck of the 747 is great. It is like being on private aviation. 16 people at the utmost, no noise from the C cabin, two or three FAs for your service. You might have somebody sitting next to you (you will have somebody sitting next to you in C). However, the seat can be empty too (there are not a lot of SWU upgraders on this route)
AND: I had some of my most interesting conversations and meetings on the LH upper deck - you can meet really interesting people there.