I no longer travel as much as I used to so I have nothing more than lower level in my hotel programs. My leisure travel is never really enough to earn status so I am moving more towards Priceline. I had my first PL stay recently saving over $100 a night for 3 nights. I got an ES so I got the free breakfast/happy hour which was an added bene. The room was a N/S King which is what I wanted but was a little scared @ the possibility of getting a smoking room.
I would definitely use PL again but probably if I knew the hotel I was going to get was 1 of 2 or 3 in that zone or the only one in that zone. Especially if the savings is great. I probably would opt for a higher points earning rate if it was only $20 more to get a specific hotel in other cases.
Mostly I think it would depend upon the specific situation and what kind of rates I could find.