Do the any of the airlines allow you to skip a connection but continue with the trip.

For example, lets say you have a trip starting at ABC which is a 50 minute flight connecting to DEF for another flight connecting to GHI. Now, lets say that you decide to skip the ABC flight and drive to DEF because of weather concerns. If you do that will you still be able to check-in at DEF and use the rest of your ticket?

Thanks!