It seems as if most people drive from San Juan area to Ponce.
What are the alternatives? Is the "air taxi" easy to get at the airport (without a reservation?)? Any other options to get from SJU to Ponce?
CO used to fly directly to Ponce, but just do the drive. You can do it in 1.5 hours, and the drive is somewhat scenic. Even if you fly to Ponce, you still probably need a car rental. PR is an island you want to get out and see, not stay at the Hilton.