Why am I reminded of this? Not sure how big a hit it was on USA TV, but John Cleese and Fawlty Towers is one of the legends of real TV comedy and has been re-run 5000 times here.

Each Episode the Hotel Name sign 'Fawlty Towers' was changed to an anagram:

A Touch of Class: FAWLTY TOWERS
The Builders: FAWLTY TOWER (the L has started to fall off)
The Wedding Party: FARTY TOWER (now the W is a bit loose)
The Hotel Inspectors: FAW TY TO WER
Gourmet Night: WARTY TOWELS
The Germans: (strange, you didn't see the sign)
Communications Problems: FAWLTY TOWER (the L seems to be loose again)
The Psychiatrist: WATERY FOWLS (aha, a glimpse of the culprit!)
Waldorf Salad: FLAY OTTERS
The Kipper and the Corpse: FATTY OWLS
The Anniversary: FLOWERY TWATS
Basil the Rat: FARTY TOWELS