I need to receive a package while on the road in San Fransisco, it'll have to be signed-for and was wondering if most hotels will be happy to sign for and accept packages for current/incoming guests?

Haven't picked the hotel yet but will call them to double check once decided.

Any experience or recommendations, for example on how the package should be addressed, etc?

Is this safe for high value items, and if not any other recommendations? For example Amex offices usually have a post receiving service, however this is for letters only.

Thanks!