Three Chimneys, Isle of Sky, Scotland. People actually fly their private planes here to have dinner.
The Fat Duck, Bray, UK. 15 minutes drive or so from Heathrow. May not be the middle of nowehere.
I've eaten in a number of such places in Italy, one in a little walled hill town, population maybe 100, between Rome and Florence that was astoundingly good. There are probably hundreds of others.
I don't know if it still exists, but there was a fabulous restaurant in Booneville, CA that grew all of its own produce and meat called the New Booneville Cafe in the Anderson Valley in northern California. It was an oasis on a bike trip. We got up at 4 AM to do the 5 mile climb (with never a flat spot in the road) between the Sonoma Valley and the Anderson Valley (I think, though my California geography is not terrific). The food was so great that we altered our trip to stay at least an extra day there.