"Italian" covers a range of styles, as I think some of the posts indicate--are you talking red sauce traditional, classic Milanese, rustic, etc., or something a bit more creative?
My personal tastes nowadays tend to run to the last, but I'm a sucker for big, robust flavors, so I'll join in the recommendation above for Lupa. My personal favorite here is Babbo, notwithstanding the noise level; be forewarned, it's a hard reservation, still. I have not yet been to Scarpetta, which is also a hard reservation, but friends I trust really liked it (and I did like L'Impero, one of his former ventures, though not Alto, his last one). I also like A Voce, though that too suffers from noise.