I had a week 1 build MB Air that I bought the first day. The next day they replaced it when I noticed that the adhesive around the screen was coming apart.
I have been using the replacement almost non-stop (8-12 hrs per day) since I got it, about 8 months now. I use it to design and help develop several B2B websites for my clients. Running Fireworks and Photoshop on the Mac side, and using Remote Desktop into a couple windows dev servers to run Visual Studio, IIS, etc.
The computer had the kernel_task and core shutdown problems, but ever since I installed coolbook, those problems went away.
I also haven't had the need for an optical drive at all, which really surprised me. All my audio / video content is from the web, ripped from DVDs on our home computer, from my HD camcorder which records directly into H.264 MOV files, or from iTunes / Amazon MP3s.