It's a 40 minute flight on AS or an hour flight on an Era Aviation Dash 8.

I've done that drive in December/January more times than I care to remember (including on winter solstice), and let's just say I wasn't doing it because I wanted to.

It's not worth your time, effort, or danger to drive it in the winter in some rental car with no snow tires. I've had a few winter Parks Highway trips that took 8 to 9 hours one way due to borderline blizzard conditions, including a couple where it snowed hard for every single of the 360 miles. Between the maniac drivers in Anchorage and Wasilla, the howling winds in Broad Pass and Healy, and the slippery 50 miles of hills between Nenana and Fairbanks, well, you get the idea. Winter in Interior Alaska is not something to toy around with.

Just fly. PFD airfare specials are out now, so it's a good time to buy.