The award redeposit fee of $150 hurts the most and also the close in fee ($75). Last year I changed my international award ticket twice since it was only $35, but I can no longer afford to do it.
On a domestic award ticket (25000 miles), it almost makes sense to forgo the miles if there is a need to redeposit.
I am going to slowly migrate to WN as I am unable to get decent award availability on international travel anyway on CO.