It all depends on where you want to go and what your into.
A great trip could be to Las Vegas, fly out either Air New Zealand, even go via FRA and fly Singapore to New York, a couple of nights there, and then onto Vegas, and then onto San Fran...that would be a great trip. Like I said, Singapore to NYC, and then Air New Zealand back, all in business, all good with miles and cash.
Or, as others have said, hit up Brazil and South America. TAP business out is great, did it in Jan this year, a week there, then business all the way to Argentinia and Lufthansa back (Dont go first with them)....again, another fantastic trip.
OR...hit up Asia. Singapore out in business, few days there, then onto anywhere really, Thailand, Hong Kong...if you were to do that, Air New Zealand back.
Loads of options for you, loads of great airlines. What are your interests and how long do you want to go? With everyones experence on here, we could plan a trip for you that you wouldnt forget!! ^