Some friends were visting an rented for 10 days. For a family of four, it was a much better deal than a hotel (they may have had to have had 2 rooms.) They said they would rent again instead of the hotel. They went through
http://www.guestinitaly.com/ and got a place near the Spanish Steps. It even included a cleaning. Seemed to be a good deal. So, if you are taking a group or want some more room it is the way to go.