Are you looking to stay inside the city or venturing out? If venturing out, and you will have a car, I would second the recommendation for Manresa. I would also highly recommend Cyrus up in Healdsburg. Over all, I have enjoyed my experiences at Cyrus more than The French Laundry.

As to SF itself, I personally think the city does far better with "mid-range" options than upscale/fine dining.