Minimum connection time US to international
 

I am planning a trip to Santiago, Chile in November. Delta has a flight from my home town to Atlanta which arrives in ATL at 7:45 pm. The connection to Santiago departs at 9:50 pm, so slightly over two hours.

On a U.S. connection, even at a big airport, I would be comfortable with a two-hour connection time. But with a flight to Chile, where the next one won't be take off til the next day, am I risking it? Should I look for a longer wait time between flights? Thanks!

If your inbound flight is on schedule, you will have more than enough time. If you worry about delays on the inbound, take an earlier flight to ATL. There's no way to predict delays.

The official minimum connection time for domestic to international, on Delta, at Atlanta is 60 minutes. So it looks like you have plenty of time. But, as has been noted, you cannot predict delays. If missing that flight to Santiago would be a disaster from your point of view (e.g. cause you to miss a vital meeting) you could consider taking an earlier flight to Atlanta.

Also if your flights are on one ticket then Delta will accommodate you in the event of a missed connection. If not, the problem of moving onto another flight will be yours and could be expensive.