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Nov 24, 20, 10:33 am
Replies: 19
Views: 557
Posted By doctoravios

Yes, I believe most of the phase III COVID-19...

Yes, I believe most of the phase III COVID-19 vaccine trials are single blinded. I guess this is to reduce costs of preparing a comparable placebo, which for deep-frozen mRNA candidates could be...
Nov 24, 20, 10:19 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

The way the wind is blowing seems to be in the...

The way the wind is blowing seems to be in the direction of vaccine requirements being key to opening international borders:

https://www.ft.com/content/8a59043d-df0d-45c1-b870-2780f06c5d1e
Nov 24, 20, 10:14 am
Replies: 19
Views: 557
Posted By doctoravios

I have huge respect for you and all the trial...

I have huge respect for you and all the trial participants who have volunteered for vaccine trials. Without you there would be no vaccine so thank you and I hope you feel better soon.

Your...
Nov 24, 20, 10:00 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

Exclusion of individuals from certain aspects of...

Exclusion of individuals from certain aspects of society if they are unvaccinated, not through lack of want - there will simply not be enough available doses for mass population vaccination within...
Nov 24, 20, 5:29 am
Replies: 19
Views: 557
Posted By doctoravios

They have done this deliberately to ensure large...

They have done this deliberately to ensure large effect sizes in the analysis. None of the trials will measure the degree to which candidate vaccines reduce viral transmission or mortality, although...
Nov 23, 20, 10:18 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

The other possibility is that both regimens are...

The other possibility is that both regimens are effective but for some reason the vaccine was less effective in Brazil (which used full dose + full dose) compared to the UK (where some people got...
Nov 22, 20, 2:18 pm
Replies: 6,732
Views: 922,662
Posted By doctoravios

But that is rather the point. The risk is not of...

But that is rather the point. The risk is not of distance. It is of being in a poorly ventilated space for a long period of time. 2m or 10m? It makes little difference to the risks of inoculation...
Nov 21, 20, 5:14 pm
Replies: 6,732
Views: 922,662
Posted By doctoravios

https://www.pfizer.com/news/press-release/press-re...

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against

I believe the Moderna results are 14 days post second dose but can't find the...
Nov 21, 20, 4:05 pm
Replies: 6,732
Views: 922,662
Posted By doctoravios

I would be very careful about making this...

I would be very careful about making this assumption. Unless I am mistaken the phase 3 trial endpoints being reported so far are at 7 days post 2nd dose. We still have absolutely no idea about longer...
Nov 21, 20, 2:50 pm
Replies: 6,732
Views: 922,662
Posted By doctoravios

I wish I could agree with you, but Perspex is no...

I wish I could agree with you, but Perspex is no match for Brownian motion.
Nov 21, 20, 6:40 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

I think one useful by-product of the hygiene...

I think one useful by-product of the hygiene theatre/er is getting people to wash their hands more. It probably makes little difference for COVID-19 (shhh - don't tell anyone!) but almost certainly...
Nov 13, 20, 7:23 am
Replies: 4,749
Views: 568,660
Posted By doctoravios

In that case perhaps there is a separate...

In that case perhaps there is a separate link/database on the BA side to record any "extras" in addition to the eVoucher. I have called again and they gave me the same information as before (i.e. the...
Nov 12, 20, 3:05 pm
Replies: 4,749
Views: 568,660
Posted By doctoravios

Edit: I thought you meant a section for used...

Edit: I thought you meant a section for used COVID-19 eVouchers but you must mean GUFs. Yes, I can see the GUF and it is marked as "Used" on the PNR of my original booking so the evidence is all...
Nov 12, 20, 5:17 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

We don't know enough about the pathophysiology...

We don't know enough about the pathophysiology and immunological correlates of mild vs severe disease yet. I should stress that this is my purely speculative opinion, but I think children's...
Nov 12, 20, 5:04 am
Replies: 4,749
Views: 568,660
Posted By doctoravios

Thanks. I called them and they said the eVoucher...

Thanks. I called them and they said the eVoucher I had has the GUF noted on it and I would need to make a booking over the phone rather than online in order to be able to access it. There is no...
Nov 12, 20, 3:36 am
Replies: 4,749
Views: 568,660
Posted By doctoravios

Apologies if this has already been covered but I...

Apologies if this has already been covered but I have requested and received an eVoucher for a booking which was original in WTP upgraded to CW using a GUF2. I understand that requesting an eVoucher...
Nov 10, 20, 4:36 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

Yes, that's quite possible and also it looks like...

Yes, that's quite possible and also it looks like from the protocol the vaccine administrators were unblinded (presumably because they didn't want to spend huge amounts of money unnecessarily cooling...
Nov 9, 20, 8:31 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

Ordinarily they wouldn't be releasing any...

Ordinarily they wouldn't be releasing any information at all until all endpoint data obtained, but this being COVID-19 I imagine they are not only keen to publish positive news but also under...
Nov 9, 20, 7:40 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

Incredible news. Full press release here: ...

Incredible news. Full press release here:

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against
...
Oct 30, 20, 9:59 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

The Oxford/AstraZeneca candidate (ChAdOX) is...

The Oxford/AstraZeneca candidate (ChAdOX) is based on a chimpanzee adenoviral vector and Sputnik-V is based on a human adenoviral vector. I am sure there are others I am not aware of in various...
Oct 13, 20, 5:04 pm
Replies: 6,732
Views: 922,662
Posted By doctoravios

For those countries which have achieved effective...

For those countries which have achieved effective suppression I think it makes sense to continue for the time being (i.e. borders remain pretty much closed and people entering undergo strict...
Oct 13, 20, 11:58 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

Absolutely - I'm not suggesting a partially...

Absolutely - I'm not suggesting a partially effective vaccine wouldn't be helpful. Anything which reduces mortality will be beneficial, as is the strategy for flu whereby partially effective vaccines...
Oct 13, 20, 11:38 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

I think it is a continuum rather than suppression...

I think it is a continuum rather than suppression vs mitigation but strict border control/quarantine, a robust surveillance and test/trace/isolate system with immediate lockdowns following the...
Oct 13, 20, 8:56 am
Replies: 6,732
Views: 922,662
Posted By doctoravios

The trouble is that herd immunity may not be...

The trouble is that herd immunity may not be possible with a vaccine either. It is highly unlikely first generation vaccines will elicit long-lasting, sterilising immune responses. We have to...
Oct 6, 20, 3:13 pm
Replies: 6,732
Views: 922,662
Posted By doctoravios

Some very interesting research underway looking...

Some very interesting research underway looking at the use of humidity microstructure data to augment mobile contact tracing and get around the problem of poor accuracy with bluetooth:
...
Showing results 1 to 25 of 291
 

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