Unique properties?
 

One of the big criticisms of Marriott writ large is that so many of the properties, across multiple brands within the portfolio, are cookie-cutter. Hence the big bush on rebranding Renaissance to boutique-esque.

Of course, there are exceptions. The London Marriott County Hall is pretty unique. As is the Marriott Los Suenos -- the latter is pretty amazing, architecturally, for a new-build (1999) hotel.

Are there any other properties like this? I see that the Marriott in San Jose is basically a twin of the Los Suenos property.

The Autograph properties are obviously Marriott's attempt at diversity. I don't think they are entirely successful, but the Mauna Kea is an example of what they should be looking at.

But what about the flagship brands, like Marriott or Renaissance? Obviously, there's the St. Pancras Renaissance.

There's two Marriott properties (a Renaissance and a Residence Inn) in Minneapolis which are built inside a historic railroad depot:

http://thedepotminneapolis.com/history/

Is that unique enough?

Meh. I live pretty much adjacent to The Depot, and it's nothing too special - the hotels themselves are new build, and the event center (and former ice rink - RIP) are really what encompass the actual historic depot. It looks nice, but I wouldn't expect anything too out of the ordinary, hotel-wise.