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WHO Coronavirus disease (COVID-19) situation reports
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Coronavirus / COVID-19 : general fact-based reporting
#5686
Suspended
Join Date: Feb 2009
Programs: DL, UA, AA, VS
Posts: 5,226
So could this be more about sizes of droplets containing virus particles? That is the heavier droplets will fall because of their weight but the lighter droplets or aerosols remain suspended in the air longer and can be carried longer distance by the HVAC.
Or they just build up and you get a cloud of aerosols. Even though they carry much less virus load per aerosol than large droplets, collectively they may pose a transmission factor if enough of them build up and form a cloud in indoor spaces where people spend a long time, such as bars, night clubs, restaurants, etc.
It would be more alarming if there would be documented cases of aerosols causing infection outside. But there's no easy way to differentiate between whether people were infected by droplets or aerosols or maybe even fomites.
#5687
FlyerTalk Evangelist
Join Date: Jun 2005
Posts: 38,410
I think you missed the vital argument. That was no randomized trial involving later-stage hospitalizations. Its group outcomes reportedly do not change much with those cases included, anyway. The earliest good RCT findings are supposedly due this September, with some interim results arriving this month.
Here is the author's explanatory text that you left out, which covers the main factor in his chronology-focused analysis of clinical experience, i.e. early HCQ treatment that brings above-background chances of hugely beneficial outcomes.
Providing full information is key to avoiding narrative shaping via omission or misinterpretation.
Here is the author's explanatory text that you left out, which covers the main factor in his chronology-focused analysis of clinical experience, i.e. early HCQ treatment that brings above-background chances of hugely beneficial outcomes.
Providing full information is key to avoiding narrative shaping via omission or misinterpretation.
#5688
FlyerTalk Evangelist
Join Date: Nov 2004
Location: 45° North
Programs: DL DM MM, HH Diamond
Posts: 10,196
#5689
Join Date: Dec 2018
Location: PHX
Programs: Delta DM, Marriott Lifetime Titanium, HHonrs Diamond
Posts: 1,336
WWWNCDC is the Emerging Infectious Disease journal made to help scholars in Asia get publications under the "CDC" name.
it is not CDC work.
And much of that work has had a very low threshold for publication and suffer from lack of peer review. So take anything from that journal with a grain of salt.
As for the elevator paper, it is a nice story, but just like the one where they plotted the tables in the restaurant with the air conditioning direction, but never tested the waitstaff, it is meh.
Remember the one that plotted the people on the same bus who all caught COVID? that one was retracted.
Also, the genetic clades seen in China are pretty tight with little variation, so not sure if it proof it came from a single source.
it is not CDC work.
And much of that work has had a very low threshold for publication and suffer from lack of peer review. So take anything from that journal with a grain of salt.
As for the elevator paper, it is a nice story, but just like the one where they plotted the tables in the restaurant with the air conditioning direction, but never tested the waitstaff, it is meh.
Remember the one that plotted the people on the same bus who all caught COVID? that one was retracted.
Also, the genetic clades seen in China are pretty tight with little variation, so not sure if it proof it came from a single source.
#5690
Join Date: Mar 2005
Programs: Continental Onepass, Hilton, Marriott, USAir and now UA
Posts: 6,423
WWWNCDC is the Emerging Infectious Disease journal made to help scholars in Asia get publications under the "CDC" name.
it is not CDC work.
And much of that work has had a very low threshold for publication and suffer from lack of peer review. So take anything from that journal with a grain of salt.
As for the elevator paper, it is a nice story, but just like the one where they plotted the tables in the restaurant with the air conditioning direction, but never tested the waitstaff, it is meh.
Remember the one that plotted the people on the same bus who all caught COVID? that one was retracted.
Also, the genetic clades seen in China are pretty tight with little variation, so not sure if it proof it came from a single source.
it is not CDC work.
And much of that work has had a very low threshold for publication and suffer from lack of peer review. So take anything from that journal with a grain of salt.
As for the elevator paper, it is a nice story, but just like the one where they plotted the tables in the restaurant with the air conditioning direction, but never tested the waitstaff, it is meh.
Remember the one that plotted the people on the same bus who all caught COVID? that one was retracted.
Also, the genetic clades seen in China are pretty tight with little variation, so not sure if it proof it came from a single source.
Red flags raised over Chinese Research Published in Global Journals
"Internationally peer-reviewed journals published more than 100 scientific research papers from China-based authors that appear to have reused identical sets of images, raising questions about the proliferation of problematic science as institutions fast-track research during the coronavirus pandemic."
There is also a similar article in Forbes published last month
Eight Fraudulent Cancer Research Studies Contained the Same Copied Results. How Does This Happen?
#5691
Join Date: May 2014
Posts: 7,218
An interesting BBC report from Wuhan, with interesting graphics on the functioning of Sars-CoV-2 - quite enlightening for the layman like me.
https://www.bbc.co.uk/news/extra/ews...ce-china-wuhan
https://www.bbc.co.uk/news/extra/ews...ce-china-wuhan
#5692
Join Date: Aug 2010
Location: California
Programs: American, SWA, United, IHG,Hilton, Hyatt, Marriott
Posts: 1,840
An interesting BBC report from Wuhan, with interesting graphics on the functioning of Sars-CoV-2 - quite enlightening for the layman like me.
https://www.bbc.co.uk/news/extra/ews...ce-china-wuhan
https://www.bbc.co.uk/news/extra/ews...ce-china-wuhan
#5693
Join Date: Dec 2018
Location: PHX
Programs: Delta DM, Marriott Lifetime Titanium, HHonrs Diamond
Posts: 1,336
And finally Common Cold Coronavirus T-cell priming makes it into the mainstream.
Joe is a character, but he does have a masters from MIT in molecular biology, so...
"It doesn't seem that high" possibly because we are not looking for it enough yet in the quest for a proprietary and profitable vaccine.
Joe is a character, but he does have a masters from MIT in molecular biology, so...
"It doesn't seem that high" possibly because we are not looking for it enough yet in the quest for a proprietary and profitable vaccine.
#5694
FlyerTalk Evangelist
Join Date: Aug 2014
Programs: Top Tier with all 3 alliances
Posts: 11,647
More accounts of lingering effects, so you don't forget or become complacent...
Richard Quest: I got Covid-19 two months ago. I'm still discovering new areas of damage
Richard Quest: I got Covid-19 two months ago. I'm still discovering new areas of damage
#5695
Suspended
Join Date: Feb 2009
Programs: DL, UA, AA, VS
Posts: 5,226
And finally Common Cold Coronavirus T-cell priming makes it into the mainstream.
Joe is a character, but he does have a masters from MIT in molecular biology, so...
https://twitter.com/SquawkCNBC/statu...55853573890048
"It doesn't seem that high" possibly because we are not looking for it enough yet in the quest for a proprietary and profitable vaccine.
Joe is a character, but he does have a masters from MIT in molecular biology, so...
https://twitter.com/SquawkCNBC/statu...55853573890048
"It doesn't seem that high" possibly because we are not looking for it enough yet in the quest for a proprietary and profitable vaccine.
I didn't see that segment but apparently NovaVax got like a $1.5 billion grant, the biggest among Project Warp Speed vaccine candidates.
Their vaccine supposedly will try to stimulate a T-cell response but the CEO admits he's not sure the vaccine will work.
The Novavax vaccine will take a different approach from the others, focusing on boosting the body's immune response by stimulating T helper cells and high levels of neutralizing antibodies.
Whether this approach has an advantage compared with other companies' vaccine candidates, which are solely focused on stimulating antibodies, has yet to be determined.
"Nobody knows for sure," Erck said Tuesday morning during a Squawk Box segment on CNBC. "It is hypothesized the T-cell response will augment what an antibody response is." The vaccine's success will be determined through the company's clinical trials, he added.
Newsweek contacted Novavax for comment but did not hear back in time for publication.
Whether this approach has an advantage compared with other companies' vaccine candidates, which are solely focused on stimulating antibodies, has yet to be determined.
"Nobody knows for sure," Erck said Tuesday morning during a Squawk Box segment on CNBC. "It is hypothesized the T-cell response will augment what an antibody response is." The vaccine's success will be determined through the company's clinical trials, he added.
Newsweek contacted Novavax for comment but did not hear back in time for publication.
#5696
Join Date: Mar 2005
Programs: Continental Onepass, Hilton, Marriott, USAir and now UA
Posts: 6,423
Although @FlitBen had already mentioned the Henry Ford study on HCQ, thought that everyone interested should be able to read the actual paper that has been published.
"Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with Covid-19"
It is an observational study with the following findings
"Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with Covid-19"
It is an observational study with the following findings
- According to a protocol-based treatment algorithm, among hospitalized patients, use of hydroxychloroquine alone and in combination with azithromycin was associated with a significant reduction in-hospital mortality compared to not receiving hydroxychloroquine.
- Findings of this observational study provide crucial data on experience with hydroxychloroquine therapy, providing necessary interim guidance for COVID-19 therapeutic practice.
#5697
Join Date: Mar 2005
Programs: Continental Onepass, Hilton, Marriott, USAir and now UA
Posts: 6,423
This is a public company. You can get into big trouble with the SEC making false forward claiming statements
#5698
Suspended
Join Date: Feb 2009
Programs: DL, UA, AA, VS
Posts: 5,226
Although @FlitBen had already mentioned the Henry Ford study on HCQ, thought that everyone interested should be able to read the actual paper that has been published.
"Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with Covid-19"
It is an observational study with the following findings
"Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with Covid-19"
It is an observational study with the following findings
- According to a protocol-based treatment algorithm, among hospitalized patients, use of hydroxychloroquine alone and in combination with azithromycin was associated with a significant reduction in-hospital mortality compared to not receiving hydroxychloroquine.
- Findings of this observational study provide crucial data on experience with hydroxychloroquine therapy, providing necessary interim guidance for COVID-19 therapeutic practice.
I saw another observational study by a doctor trying to promote Famotidine and Zyrtec as a "double antihistamine" therapy for C19. He's actually trying to patent the idea.
They obviously didn't have a control arm so he published his findings vs. the observed data from other sources for how people who didn't take these two antihistamines fared.
#5699
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Join Date: Feb 2009
Programs: DL, UA, AA, VS
Posts: 5,226
The Moderna people especially the CEO are known to be huge self-promoters.
This NovaVax CEO's comment was notable because it was in contrast to what the others connected to other vaccine efforts have said publicly. That and the fact that his company is getting $1.5 billion from the govt.
#5700
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Join Date: Feb 2009
Programs: DL, UA, AA, VS
Posts: 5,226
Researchers from Univ. of Arizona and Univ. of South Florida have tested and identified 4 protease-inhibitors which have shown antiviral activity against the virus in the lab.
https://www.nature.com/articles/s41422-020-0356-z
Interesting is that they reference some other antivirals which did not work as well, such as some AIDS drugs, camostat and others.
Using the FRET-based enzymatic assay, several inhibitors including boceprevir, GC-376, and calpain inhibitors II, and XII were identified to have potent activity with single-digit to submicromolar IC50 values in the enzymatic assay. The mechanism of action of the hits was further characterized using enzyme kinetic studies, thermal shift binding assays, and native mass spectrometry. Significantly, four compounds (boceprevir, GC-376, calpain inhibitors II and XII) inhibit SARS-CoV-2 viral replication in cell culture with EC50values ranging from 0.49 to 3.37 µM. Notably, boceprevir, calpain inhibitors II and XII represent novel chemotypes that are distinct from known substrate-based peptidomimetic Mpro inhibitors. A complex crystal structure of SARS-CoV-2 Mpro with GC-376, determined at 2.15 Å resolution with three protomers per asymmetric unit, revealed two unique binding configurations, shedding light on the molecular interactions and protein conformational flexibility underlying substrate and inhibitor binding by Mpro. Overall, the compounds identified herein provide promising starting points for the further development of SARS-CoV-2 therapeutics.
Interesting is that they reference some other antivirals which did not work as well, such as some AIDS drugs, camostat and others.