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Coronavirus / COVID-19 : general fact-based reporting
#4591
Join Date: Jan 2013
Location: Hawai'i Nei
Programs: Au: UA, Marriott, Hilton; GE
Posts: 7,139
Use of Goggles Recommended
In case this hasn't otherwise been reported here, in an advisory issued yesterday, the American Academy of Opthalmology recommends using googles along with masks as a measure to prevent COVID-19 infection:
https://www.aao.org/headline/alert-i...avirus-context
Just for example, with bolding theirs:
"Therefore, protecting your mouth, nose (e.g., an N-95 mask) and eyes (e.g., goggles or shield) is recommended when caring for patients potentially infected with COVID-19."
Don't know why more people are not walking around using goggles. I am.
https://www.aao.org/headline/alert-i...avirus-context
Just for example, with bolding theirs:
"Therefore, protecting your mouth, nose (e.g., an N-95 mask) and eyes (e.g., goggles or shield) is recommended when caring for patients potentially infected with COVID-19."
Don't know why more people are not walking around using goggles. I am.
#4592
Join Date: Mar 2011
Location: BDL, JFK
Posts: 658
In case this hasn't otherwise been reported here, in an advisory issued yesterday, the American Academy of Opthalmology recommends using googles along with masks as a measure to prevent COVID-19 infection:
https://www.aao.org/headline/alert-i...avirus-context
Just for example, with bolding theirs:
"Therefore, protecting your mouth, nose (e.g., an N-95 mask) and eyes (e.g., goggles or shield) is recommended when caring for patients potentially infected with COVID-19."
Don't know why more people are not walking around using goggles. I am.
https://www.aao.org/headline/alert-i...avirus-context
Just for example, with bolding theirs:
"Therefore, protecting your mouth, nose (e.g., an N-95 mask) and eyes (e.g., goggles or shield) is recommended when caring for patients potentially infected with COVID-19."
Don't know why more people are not walking around using goggles. I am.
#4593
Join Date: Dec 2018
Location: PHX
Programs: Delta DM, Marriott Lifetime Titanium, HHonrs Diamond
Posts: 1,336
https://nltimes.nl/2020/04/16/3-dutc...-19-antibodies
The primary source mentioned in the article is in Dutch, so if anyone can translate and find more information it would be helpful. Would love to know which test they used and the sensitivity/specificity of it. Blood donation is not fully representative of population as it excludes the very young and very old.
But if 3% of non-cases have antibodies and around the midpoint of the study there were 20,000 cases diagnosed. https://www.worldometers.info/corona...y/netherlands/
3% of a population of 17 million is 510,000 infections for those 20,000 cases or a 25x multiplier of cases to estimate infections.
The primary source mentioned in the article is in Dutch, so if anyone can translate and find more information it would be helpful. Would love to know which test they used and the sensitivity/specificity of it. Blood donation is not fully representative of population as it excludes the very young and very old.
But if 3% of non-cases have antibodies and around the midpoint of the study there were 20,000 cases diagnosed. https://www.worldometers.info/corona...y/netherlands/
3% of a population of 17 million is 510,000 infections for those 20,000 cases or a 25x multiplier of cases to estimate infections.
#4594
Join Date: Jan 2013
Location: Hawai'i Nei
Programs: Au: UA, Marriott, Hilton; GE
Posts: 7,139
I really don’t understand people who think civilians wouldn’t benefit from the same protection afforded health care workers.
#4595
FlyerTalk Evangelist
Join Date: May 2015
Location: BOS, YVR, ZRH
Programs: *G
Posts: 17,397
Emirates Airline Begins Conducting Rapid COVID-19 Tests For Boarding Passengers
"In a move that could be a step toward making air travel palatable to the public again, Emirates Airline has begun conducing rapid-on site COVID-19 for passengers.The testing began with passengers on a flight from Dubai to Tunisia on Wednesday. The analysis is a blood test with results within 10 minutes. The airline says it is the first to roll out rapid testing."
https://www.npr.org/sections/coronav...ing-passengers
"In a move that could be a step toward making air travel palatable to the public again, Emirates Airline has begun conducing rapid-on site COVID-19 for passengers.The testing began with passengers on a flight from Dubai to Tunisia on Wednesday. The analysis is a blood test with results within 10 minutes. The airline says it is the first to roll out rapid testing."
https://www.npr.org/sections/coronav...ing-passengers
Last edited by NewbieRunner; Apr 17, 2020 at 10:05 am Reason: Font size
#4596
Join Date: Aug 2010
Programs: AA EXP
Posts: 1,659
I wear an N95 mask and goggles when I go to the grocery store. Last flight I had was March 11th and I wore an N95 mask for about 4 hours. Definitely uncomfortable but worth it, only way I was going to sit next to a stranger and this was a bed in J on an AA 757.
#4597
A FlyerTalk Posting Legend
Join Date: Aug 2002
Location: NY Metro Area
Programs: AA 2MM Yay!, UA MM, Costco General Member
Posts: 49,036
#4598
Join Date: Dec 2018
Location: PHX
Programs: Delta DM, Marriott Lifetime Titanium, HHonrs Diamond
Posts: 1,336
Sorry I did not comment on the Emirates story when it was first linked here. Their press release: https://www.emirates.com/media-centr...or-passengers/
They are using a blood test and no virus is not present in blood. Therefore they are not detecting live virus but most likely antibodies.
In the Nature study I have quoted in the past...
the earliest antibodies appeared on day 5 after symptoms and all by Day 14.
Between Day 8 and Day 14, some people not shedding infectious virus anymore were still not antibody positive.
Since people can be contagious prior to symptoms for 3 days and antibodies take at least 5 days to develop, One could be anywhere in that 8-day contagious window and still board the flight.
Their test may look for IgM antibodies and not allow those passengers to fly since those are the "recent infection" antibodies but still many infected people are asymptomatic for days and many have no symptoms. Another group who are IgM positive may not be contagious anymore, but there is no way to confirm that in short order.
For a plane with 300 passengers on it, this might catch 2-3 people, 1 of which may not be contagious anymore, and would falsely assure another 2-3 who are early in the infection process. Still, the old temperature gun, that has precision at body temperature (not a temperature gun used to measure kitchen ovens and freezers) is probably better. Of course that can be defeated with some Tylenol and a little luck.
#4599
Join Date: May 2000
Location: IAH
Programs: UA 1K 2.7MM, Marriott Titanium/LT Plat, IHG Spire
Posts: 3,317
This seems like hopeful news: 125 people treated with Remdesivir in a Chicago hospital, 113 of those with "severe" cases of Covid-19. Only 2 perished. Most have been discharged after about six days of hospitalization.
https://www.statnews.com/2020/04/16/...-to-treatment/
https://www.statnews.com/2020/04/16/...-to-treatment/
Last edited by JNelson113; Apr 16, 2020 at 4:55 pm
#4600
Join Date: Dec 2018
Location: PHX
Programs: Delta DM, Marriott Lifetime Titanium, HHonrs Diamond
Posts: 1,336
You will pick up more virus on a lavatory counter or door handle than will be in the air around your seat.
When multiple patients in a cabin test positive (J cabin of the London-Hanoi flight 54 for example), the distribution of positives points more toward shared lavatory, not shared or nearby personal air spaces.
This seems like hopeful news: https://www.statnews.com/2020/04/16/...-to-treatment/
Gilead stock took a hit this AM when China halted trials on the same drug. Wait. That China? The one that doesn't have many new cases? Seemed like a strange announcement to me. This link above released after the market closed today (but stock could still be bought after hours and is up 10-15%) could be a rebuttal to that hit.
This severe patient arm of the trial is not controlled (compassionate use designation) while the mild case arm is controlled.
Data collection will end in a couple of days and we will hopefully see the full report by end of month (the mild case study arm will be next month). If this can reduce ICU days, prevent conversion of high oxygen use to intubation or reduce death rate in severe cases by more than 50%, then it is a win. Anything in between and it will be hard to value without controls.
Last edited by FlyBitcoin; Apr 16, 2020 at 5:03 pm Reason: Added study result date
#4601
Suspended
Join Date: Oct 2004
Location: Bay Area
Programs: DL SM, UA MP.
Posts: 12,729
This seems like hopeful news: https://www.statnews.com/2020/04/16/...-to-treatment/
Dow futures were up as high as 700 and Gilead stock was up 15% in after hours.
It's not even a formal release of a report and the information is about results without a control group.
“The best news is that most of our patients have already been discharged, which is great. We’ve only had two patients perish,” said Kathleen Mullane, the University of Chicago infectious disease specialist overseeing the remdesivir studies for the hospital.
Her comments were made this week during a video discussion about the trial results with other University of Chicago faculty members. The discussion was recorded and STAT obtained a copy of the video.
The outcomes offer only a snapshot of remdesivir’s effectiveness. The same trials are being run concurrently at other institutions, and it’s impossible to determine the full study results with any certainty. Still, no other clinical data from the Gilead studies have been released to date, and excitement is high. Last month, President Trump touted the potential for remdesivir — as he has for many still-unproven treatments — and said it “seems to have a very good result.”
In a statement Thursday, Gilead said: “What we can say at this stage is that we look forward to data from ongoing studies becoming available.”
Gilead had said to expect results for its trial involving severe cases in April. Mullane said during her presentation that data for the first 400 patients in the study would be “locked” by Gilead Thursday, meaning that results could come any day.
Mullane, while encouraged by the University of Chicago data, made clear her own hesitancy about drawing too many conclusions.
[b[“It’s always hard,” she said, because the severe trial doesn’t include a placebo group for comparison. “But certainly when we start [the] drug, we see fever curves falling,” she said. “Fever is now not a requirement for people to go on trial, we do see when patients do come in with high fevers, they do [reduce] quite quickly. We have seen people come off ventilators a day after starting therapy. So, in that realm, overall our patients have done very well.”[/b]
She added: “Most of our patients are severe and most of them are leaving at six days, so that tells us duration of therapy doesn’t have to be 10 days. We have very few that went out to 10 days, maybe three,” she said.
Her comments were made this week during a video discussion about the trial results with other University of Chicago faculty members. The discussion was recorded and STAT obtained a copy of the video.
The outcomes offer only a snapshot of remdesivir’s effectiveness. The same trials are being run concurrently at other institutions, and it’s impossible to determine the full study results with any certainty. Still, no other clinical data from the Gilead studies have been released to date, and excitement is high. Last month, President Trump touted the potential for remdesivir — as he has for many still-unproven treatments — and said it “seems to have a very good result.”
In a statement Thursday, Gilead said: “What we can say at this stage is that we look forward to data from ongoing studies becoming available.”
Gilead had said to expect results for its trial involving severe cases in April. Mullane said during her presentation that data for the first 400 patients in the study would be “locked” by Gilead Thursday, meaning that results could come any day.
Mullane, while encouraged by the University of Chicago data, made clear her own hesitancy about drawing too many conclusions.
[b[“It’s always hard,” she said, because the severe trial doesn’t include a placebo group for comparison. “But certainly when we start [the] drug, we see fever curves falling,” she said. “Fever is now not a requirement for people to go on trial, we do see when patients do come in with high fevers, they do [reduce] quite quickly. We have seen people come off ventilators a day after starting therapy. So, in that realm, overall our patients have done very well.”[/b]
She added: “Most of our patients are severe and most of them are leaving at six days, so that tells us duration of therapy doesn’t have to be 10 days. We have very few that went out to 10 days, maybe three,” she said.
Gilead’s severe Covid-19 study includes 2,400 participants from 152 different clinical trial sites all over the world. Its moderate Covid-19 study includes 1,600 patients in 169 different centers, also all over the world.
The trial is investigating five- and 10-day treatment courses of remdesivir. The primary goal is a statistical comparison of patient improvement between the two treatment arms. Improvement is measured using a seven-point numerical scale that encompasses death (at worst) and discharge from hospital (best outcome), with various degrees of supplemental oxygen and intubation in between.
The lack of a control arm in the study could make interpreting the results more challenging.
The trial is investigating five- and 10-day treatment courses of remdesivir. The primary goal is a statistical comparison of patient improvement between the two treatment arms. Improvement is measured using a seven-point numerical scale that encompasses death (at worst) and discharge from hospital (best outcome), with various degrees of supplemental oxygen and intubation in between.
The lack of a control arm in the study could make interpreting the results more challenging.
Would be interesting that a drug developed for Ebola treatment, which it failed at, may have some action against this new virus.
#4602
A FlyerTalk Posting Legend
Join Date: Aug 2002
Location: NY Metro Area
Programs: AA 2MM Yay!, UA MM, Costco General Member
Posts: 49,036
The N95 mask on an airplane is only as good as your hand washing and attention to surfaces.
You will pick up more virus on a lavatory counter or door handle than will be in the air around your seat.
When multiple patients in a cabin test positive (J cabin of the London-Hanoi flight 54 for example), the distribution of positives points more toward shared lavatory, not shared or nearby personal air spaces.
it is promising, but now for the rest of the story....
Gilead stock took a hit this AM when China halted trials on the same drug. Wait. That China? The one that doesn't have many new cases? Seemed like a strange announcement to me. This link above released after the market closed today (but stock could still be bought after hours and is up 10-15%) could be a rebuttal to that hit.
This severe patient arm of the trial is not controlled (compassionate use designation) while the mild case arm is controlled.
Data collection will end in a couple of days and we will hopefully see the full report by end of month (the mild case study arm will be next month). If this can reduce ICU days, prevent conversion of high oxygen use to intubation or reduce death rate in severe cases by more than 50%, then it is a win. Anything in between and it will be hard to value without controls.
You will pick up more virus on a lavatory counter or door handle than will be in the air around your seat.
When multiple patients in a cabin test positive (J cabin of the London-Hanoi flight 54 for example), the distribution of positives points more toward shared lavatory, not shared or nearby personal air spaces.
it is promising, but now for the rest of the story....
Gilead stock took a hit this AM when China halted trials on the same drug. Wait. That China? The one that doesn't have many new cases? Seemed like a strange announcement to me. This link above released after the market closed today (but stock could still be bought after hours and is up 10-15%) could be a rebuttal to that hit.
This severe patient arm of the trial is not controlled (compassionate use designation) while the mild case arm is controlled.
Data collection will end in a couple of days and we will hopefully see the full report by end of month (the mild case study arm will be next month). If this can reduce ICU days, prevent conversion of high oxygen use to intubation or reduce death rate in severe cases by more than 50%, then it is a win. Anything in between and it will be hard to value without controls.
#4603
Join Date: Jan 2013
Location: Hawai'i Nei
Programs: Au: UA, Marriott, Hilton; GE
Posts: 7,139
The N95 mask on an airplane is only as good as your hand washing and attention to surfaces.
You will pick up more virus on a lavatory counter or door handle than will be in the air around your seat.
When multiple patients in a cabin test positive (J cabin of the London-Hanoi flight 54 for example), the distribution of positives points more toward shared lavatory, not shared or nearby personal air spaces.
You will pick up more virus on a lavatory counter or door handle than will be in the air around your seat.
When multiple patients in a cabin test positive (J cabin of the London-Hanoi flight 54 for example), the distribution of positives points more toward shared lavatory, not shared or nearby personal air spaces.
#4604
Join Date: Dec 2018
Location: PHX
Programs: Delta DM, Marriott Lifetime Titanium, HHonrs Diamond
Posts: 1,336
Since hand washing or surfaces were not brought up, only the N95, I just wanted to make it clear that 100% risk mitigation of the lower threat (which an N95 will do) is only as good as the strength in the mitigation of the higher threat (surfaces) which requires a multi-modal approach.
And if you flew 747's, I don't need to tell you about risk stratification, so please don't take anything personally.
#4605
Join Date: Jan 2013
Location: Hawai'i Nei
Programs: Au: UA, Marriott, Hilton; GE
Posts: 7,139
No. It was not directed at you per se. More directed toward the group.
Since hand washing or surfaces were not brought up, only the N95, I just wanted to make it clear that 100% risk mitigation of the lower threat (which an N95 will do) is only as good as the strength in the mitigation of the higher threat (surfaces) which requires a multi-modal approach.
And if you flew 747's, I don't need to tell you about risk stratification, so please don't take anything personally.
Since hand washing or surfaces were not brought up, only the N95, I just wanted to make it clear that 100% risk mitigation of the lower threat (which an N95 will do) is only as good as the strength in the mitigation of the higher threat (surfaces) which requires a multi-modal approach.
And if you flew 747's, I don't need to tell you about risk stratification, so please don't take anything personally.
From February, I've been seeing lots of posts saying masks are not needed, blah blah blah. Even properly applied N95s are not 100 percent effective, or else they would be called N100s.