I don't think that I could justify there and Katz's, and I'd be really bummed out if I skipped Katz's. Pastrami is always a personal taste (I have a friend who swears that Ben's out in Queens makes better pastrami than any of the Manhattan Delis), but I found Second Avenue's pastrami and other food to be too salty, anyway.
Hmm, might go there for cheesecake at 3 am. . . .
Sorry, no cheesecake. They are kosher so they cannot mix meat and dairy.