I rolled my eyes once when I was transferring through SFO, from EWR, on my way to SYD, and overheard a woman telling her companion she hoped she would survive the long flight to Chicago...
I have to remember sometimes that for some more grounded/normal people, a single international trip is a big deal, like only a few times in their life. Versus once a month for me.
Although I don't travel internationally once a month, I fly trans pac every three month or so.
I can say that when my upgrade doesn't clear, I worry about how I will survive long flight from JFK to LAX/SFO.